Of course it is your decision but in my experience, having had an RX450 F Sport with the ML system for 4 years prior to our current NX450h F Sport, I wouldn’t let the lack of the ML system be a deal breaker. TBH I never rated the ML in the RX and I certainly find the standard system in the NX450 to be comparable to the ML in the RX.
The pano roof I agree with. It is something that we miss in the NX450 F Sport, the little sunroof is no substitute, but I went for the F Sport because I really wanted the adaptive suspension, which just shows that we all have individual preferences.