I agree with most of what Linas.P said - now starting to get a little long in the tooth, lacking performance, practicality issues - all compared to alternative and newer stuff. However, I feel that that running costs (high fuel prices) is one of the major factors. For example, when I got my 250C over a year ago fuel was costing me £30 to £35 per week. Right now (June 2022) it's costing £50. Per week. I'm driving like grandma on the daily and just managing to squeeze 34mpg out of it, plus some doodling about at the weekend, shopping etc.
Now, I happen to think that 34mpg is quite reasonable for a 2.5L V6, but nevertheless there are more economical cars around, and this could be a big reason why some owners are getting rid. Car sharing isn't really an option for me and I'm even considering getting an old oil burning banger for the time being and SORN-ing the 250 until petrol cost returns to a reasonable price.
That being said, I had planned to keep the 250 for at least another 2 - 3 years, as it's a lovely, dependable and comfortable car and it's also in good nick.
Finally, and I wasn't going to mention this, but hey ho.
Weapon of choice these days is the SUV and the traditional 'family saloon' is seen by some as being a bit dated. I also think that some private IS250 sellers may be doing so sadly to downgrade and get a small pot of cash to supplement their incomes. Times are indeed hard at the moment.