We've got the same problem with our 2008 IS250.
The battery and alternator are fine, so we had an electric specialist come and have a look. We learned that there's a parasitic drain from the onboard body control module which is discharging the vehicle when it's switched off. The body control module also powers the audio module which is another item that can sometimes have this parasitic drain problem.
Either way it needs repairing or replacing and 'regular' garages don't seem to have the software or coding skills needed to fix it. So it will have to go to Lexus & that's going to cost a lot! 😞
Has anyone managed to remedy the problem? If so, how and how much did it cost?