Hi Kole,
Wellllll, as coincidence has it - - I moved from my (rather wonderful) S500 to a 2014 RX-450h just two months ago.
I just loved the S Class, - its comfort, its wonderful get-up-and-go (!) and its feeling of solid dependability.
(I also achieved an annual ave of 30mpg - which was a surprise)
The RX 450 is SO different, - - yes - the CVT box is strange at first, (and the car is nowhere near as quick) - but it's certainly quick enough, I'm achieving the same mpg around my hilly town journeys - but the plus factors are great: Excellent vision, wonderful comfort, and (at my age) it is SO much easier to climb down from a car, rather than climb out of it!. I wouldn't go back to the S500 now.