My experience is that whilst I only get about a 5% improvement in mpg using premium fuel, (or, now, E10 with a fuel additive), I feel more comfortable hoping that the claimed additive ingredients counter some of the possible adverse effects of E10. And I've convinced myself that the engine is smoother, - (it isn't of course, but I'd like to think so!)
Most importantly, - my mpg has improved over the few years I've had the RX, not because of magic, but I've learned how to drive it more efficiently in different road/traffic conditions. It helps that I'm never in a scalding rush to get anywhere!