As mentioned before, I was a taxi driver for over 22 years, clocking up well over a million miles personally in many vehicles, and had several other vehicles I rented out to other drivers doing mega miles.
I used to buy them at about 100k, and taking many to 200k.
All meticulously maintained, with a lot of preventative maintainance.
All serviced every 10k miles.
Never stranded at the side of the road, and never had to limp home.
Many of my friends and colleagues didn't do the same.
One or two had engine problems, but by far the biggest killers of cars was low coolant and cambelts snapping.
Really, many of you are making mountains out of mole hills.
If you're doing 10k per year in a Lexus, service once a year and save yourself money, and be done with it.