Hi Steve. I've had 2 is300h and a RX450h and now the most superb is250. As far as comfort goes to me there's no difference between the cars I've had except for one thing. The RX is superb to get in and out of because of it being taller. Handling of the RX was rather good and way better than the anti lexus reviews of the car. Not sure if 2.5k can get a RX400h or a RX300 but it'll get you a decent is250. I can't comment on the is200 or is300 except the 200 looks lovely. Happy hunting for your car.