Just the 'lowly' 300h RC for me but the AVS is very noticeable in the different modes. Much more so than my previous MB CLS55 on AIRmatic.
I tend to use Normal around town/urban driving. The suspension tightens nicely on fast roundabouts etc.. but is nice and compliant on the less than smooth roads. Also I don't need the accentuated throttle response in traffic, nor the tightened steering response one gets in the Sport/Sport+ modes.
On the open roads it's Sport mode all the way! Sports+ if I want to 'play' but it's really too firm for normal driving on roads round here, mid corner bumps really upsets the handling.
As David suggests, double check you actually have AVS, I thought it was optional on the '18 model year?