Hi Rowley, I had a 2008 IS250 SE-L for a year, then a 2009 IS250C SE-L for a couple of years before my RX which I got nearly 5 years ago.
Yes, the doors are wider and great for access, you're correct, need to be a bit more savvy when choosing parking spots. Mine didn't have run-flats, but did have the TPMS. Rear camera too.
I had no trouble with the roof electrics so can't comment. The boot space with top up is cavernous, I once had a 4x12 Marshall speaker cabinet in there. With the roof stowed there's enough room for 2 or 3 supermarket carriers. Back seat is always available for stuff too.
The rear seat space is somewhat smaller than the saloon, but useable for kiddies and smaller stature adults for short journeys.
At the time we had ours we needed two vehicles. We're now retired and one vehicle suffices. I'd have another 250C in a heartbeat if I could justify a second car.
That's the practicalities discussed. Most of all...we had fantastic times in ours discovering the west Wales coastline from Aberaeron to Saundersfoot. Any fine weather we'd take a day out, even if it's a wee bit cooler, the heater and heated seats made for a very comfortable experience (wind deflector is essential).
Hope this helps.