Hi Colin, I don't think it is the effect of the LHD or THD (Toyota Hybrid Drive == LHD) construction itself. I have also the Prius 2G (THD 2004), of course, it has smaller engine, but its natural (normal) vibrations are just like in IS300h (a little stronger due to weaker damping), except the vibrations @1300rpm. I drove 200kkm and never had such issue. Only small shaking when the ICE is starting / stopping on low speed just like in the IS. No constant, resonant vibrations at all. There is no a rpm meter on board, however I'm pretty sure, that Prius on a common, out of the city speeds like 70-80kmph, has also very low rpms, close to the 1200-1300.