Owned an IS200 for 2 years. The issue with worn tyres is super common. There is a garage capable of adjusting the camber, if anyone remembers their name please indicate it for any future owner. After I had that camber change (about £150) I never had a problem again with uneven tyre wear.
other issues, well let me say. When the car worked well, it was a joy to drive. But when things went wrong, and in my case they did, the cost was through the roof. I've had broken wheel bearing, broken speed sensor, head gasket failure . All before 90,000 miles. Mpg is dreadful for a car like this. I also found that some mechanics completely refused to touch a lexus, telling me that the cars are well over engineered. I can vouch for this as I did my own stereo upgrade and although the electrics were easy to do, the amount of fastening and cable ties that I had to undo to get to the cables of interest was crazy. Fantastic in one way as it explains the lack of strange noises even when going over rough terrain. But you can see that if this is how the whole car is made, mechanics could be put off working on one.