Yes, indeed. There are a couple of lowering springs that are either compatible with, or have been developed for, the 450h eg RSR Down Sus
http://www.rs-r.com/product/lexus-gs-450h-rwd-down-sus-springs-2013/
I haven't driven a 4th gen 450h with the adaptive dampers.
If the F-sport 450h has slightly lower springs, I'd expect it to handle a little better in normal mode, in comparison to normal mode in the Luxury version. And if it does, then that would suggest that lowering springs would help someway. However, I understand there are other factors in the mix, including different anti roll bars and bigger wheels (dampers in normal mode). I'd expect the rear steer to effect handling more than body roll.
However, this is new territory for me and I appreciate the thought provoking input. I'll have to buy an F-sport 😛