I've been pretty pleased with the 2005 RX300SE that I bought for my wife in March. It compliments my LS 400 nicely and my wife loves it. We now use it exclusively to transport the grand kids. Downside is fuel consumption, best of 28 and low of 19, but it is an auto with 4 wheel drive and isn't exactly light. Underneath isn't very well protected, so have a look there, plus I went for the steel spring variant as I don't like air, nor CVT transmission of 400 models.
Compared to the LS, it isn't as refined, but neither was it as expensive new - different story used though lol.
It had a full lexus service history, but I had to replace a rear caliper, pads and handbrake mechanism after 6 months, so due diligence is the answer - discs were new though.
Pete