Fuel economy isn't the car's strong point, as has been said, but it depends on how you drive. I typically get about 31mpg out of mine, but that tends to be a mixture of short and longer drives.
It's a buyers market at the moment, so decide what sort of spec you want, take a look at a few and drive some so you get an idea of how they feel, and wait till you find that feels really right.
The cam belt change interval says 100K miles/10 years in the service book, but Lexus changed that to 60K miles/6 years, so make sure that's been done depending on the mileage.
Also, make sure you get more than one key with the car, and at least one "master" key (which can be identified by the fact that when you put the key into the ignition, the flashing Security light on the dashboard extinguishes immediately, as opposed to coming on for a second when you insert it). Without master keys you can't programme any more keys for the car (e.g. if you lose your keys) without a *very* big bill.