Yes I have...almost.
I only use Android auto, but I believe the unit I fitted also works with Apple carplay but I have no Apple kit to test this (which is why I say "almost" above).
The car is a 2016 IS Premier with the ML system. The sound quality is as good as it ever was. You can easily switch between the Lexus systems and the new AA/Carplay systems.
The only thing I have found not to work is when using Spotify the next track/previous track buttons on the head unit don't work, but the ones on the steering wheel and the ones on the screen (via the joystick) work fine, so I'm happy with this.
I didn't go for the larger screen version as the large screen version I found was for a touch screen, and I can't reach the screen in my IS when I'm driving - you may sit closer to the screen than me as I'm over 6ft tall! Plus the large screen version was more than double the price
It was quite easy to fit following the instructions provided with the kit, plus the vendor is really helpful if you get stuck
I ordered my system from Icebox auto and (from memory) it was around £300, and I'm very happy with it. I use Waze and Spotify mainly
Hope that helps and good luck