This weekend, I made the 500 mile round trip to my parent's place in London. I switched the suspension to comfort once on the dual carriageway (too bouncy for normal use in my opinion), and the car was great.
The radar guided cruise control together with the Lane Keep Assist were the stars of the journey though. By day or night, they kept up with traffic, braked as necessary when traffic bunched up, and helped to steer the car. This made a huge difference to stress levels, and the 3.5 hour journey each way felt like it had taken only half as long. Even in lane 3 on the M1 where vehicles can go from 'quite fast', to braking heavily to 60mph or less, the radar cruise handled it perfectly, although it took a little while to trust the system (if you brake, then the cruise turns off and you have to finish braking yourself).
Now the next bit is carefully worded... Hypothetically, if I had been tailgated at 90mph by someone in a red car, then putting the throttle to the floor for a few seconds would have left them back a good 600 yards and would have felt very good :-)
And the LS460 managed 29mpg fully loaded with family and their luggage while maintaining a decent rate of progress.