At the risk of stating the bleedin' obvious - jack the car up, undo the nuts (noting the two replies above) and pull the wheel off. Maybe you've done all that and the wheel won't come off? Very common where a wheel hasn't been removed for a while - it's caused by corrosion between the wheel face and the hub. One way (which I must admit has never worked for me) is to put the nuts back and tighten them, then back off one turn. Now lower the car off the jack, shake the car from side to side, then raise it again. The wheel might be free. What does work, but it can be dodgy if you're only using the standard jack - get a long (5' or so) plank of wood (eg 4" x 2"), go behind or in front of the car and swing the wood, holding it by one end, from the centre of the car and bash the lower inside edge of the tyre. It might take a couple of goes, but the wheel will come off. I'd advise you to have someone pushing against the car in the opposite direction to your 'bash', or support it with something more solid than the standard jack. Be very, very, careful! If it still won't come off, tighten the nuts properly and go to a tyre place. They'll do it for you!
When you put the wheel back, smear a bit of copper grease on the mating face of the hub. That will help prevent the sticking happening again.