Audio problems and other!

[MCR]

I have a IS250C, 2010 with only 34,000 on the clock, full history, with recent services by Lexus.  I am only the second owner, so it’s in good nick!  I have just had a problem, or problems, with the centre screen etc and would be grateful for advice.  Firstly, the ‘beep’ has gone despite it, apparently, being switched on on the control panel.  More importantly, all audio functions have disappeared- neither the radio or the CD etc work (won’t switch on) and even the audio adjustment screen (the one with fade, balance etc) show the sliders but no controls.  Bluetooth also seems defunct.  Satnav works as does climate.  Any idea please?  The tyre pressure warning light is also on, but I assume this is a separate issue with the sensor.  When I locked it up yesterday all was well, when I switched it on, it wasn’t.  I’ve looked a the fuse diagram but can’t see one which connected everything (althoug hi will check physically in the morning).  Thanks for any help.